Response to granulocyte macrophage colony-stimulating factor

Across TCGA cell cohorts, RNA activity of the Response to granulocyte macrophage colony-stimulating factor pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZFP36, ZFP36L2, and PRR15L, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to granulocyte macrophage colony-stimulating factor activity versus ZFP36 in SOFT_TISSUE (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ZFP36 →	+2.149	+0.656	<.001	.002	3	12
OESOPHAGUS	ZFP36L2 →	+1.362	+0.205	.003	.007	2	13
BREAST	PRR15L →	+2.404	+0.206	<.001	.006	3	7
STOMACH	DBF4B →	-0.652	-0.133	<.001	.002	3	7
OESOPHAGUS	CMTM3 →	-2.689	-0.262	<.001	<.001	3	7
STOMACH	MRC2 →	-2.765	-0.168	.003	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097012 vs ZFP36 — SOFT_TISSUE

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