Energy homeostasis

Across TCGA patient cohorts, RNA activity of the Energy homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP2U1, SPATA20, and AHCYL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Energy homeostasis activity versus CYP2U1 in BRCA (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CYP2U1 →	+0.647	+0.188	<.001	.002	3	5
OV	SPATA20 →	+0.532	+0.200	.001	.003	3	4
GBM	AHCYL1 →	+0.532	+0.139	.004	.003	3	4
OV	TMC4 →	+0.744	+0.199	.005	<.001	3	4
BRCA	CRTAP →	+0.412	+0.145	.004	.004	3	4
BRCA	BET1L →	+0.481	+0.149	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097009 vs CYP2U1 — BRCA

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