Energy homeostasis

Across TCGA cell cohorts, RNA activity of the Energy homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF624, MT2A, and DNAJC9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Energy homeostasis activity versus ZNF624 in PANCREAS (Pearson r = -0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ZNF624 →	-0.558	-0.355	<.001	.003	3	4
STOMACH	MT2A →	-3.295	-0.312	.002	.005	3	4
LUNG_SCLC	DNAJC9 →	-0.910	-0.233	<.001	<.001	3	4
CNS	ADO →	-0.404	-0.230	<.001	<.001	3	4
SOFT_TISSUE	ITIH4 →	-1.290	-0.297	.002	<.001	3	3
LUNG_NSCLC_LUSC	RC3H2 →	-1.186	-0.294	.002	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097009 vs ZNF624 — PANCREAS

Explore this scatter interactively →