Telomerase RNA localization

Across TCGA patient cohorts, RNA activity of the Telomerase RNA localization pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AGPAT5, UCHL1, and RCC2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomerase RNA localization activity versus AGPAT5 in OV (Pearson r = -0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	AGPAT5 →	-0.404	-0.041	.001	<.001	3	6
UCEC	UCHL1 →	+0.831	+0.067	<.001	.001	3	6
LUAD	RCC2 →	+0.150	+0.023	.002	.003	3	6
UCEC	MSH2 →	+0.285	+0.075	<.001	<.001	3	5
LSCC	POLR3D →	+0.206	+0.041	.001	.003	3	5
LUAD	ZNF148 →	+0.156	+0.036	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090672 vs AGPAT5 — OV

Explore this scatter interactively →