Telomerase RNA localization

Across TCGA patient cohorts, RNA activity of the Telomerase RNA localization pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DACT3, HTR2A, and CXCL12, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomerase RNA localization activity versus DACT3 in OV (Pearson r = -0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DACT3 →	-0.586	-0.100	.005	.005	3	5
GBM	HTR2A →	-0.893	-0.138	<.001	.002	3	5
OV	CXCL12 →	-1.639	-0.134	<.001	<.001	3	5
COAD	BCL2A1 →	-1.448	-0.157	<.001	<.001	3	5
LSCC	SPARCL1 →	-0.580	-0.063	<.001	.005	3	5
OV	NEXN →	-1.274	-0.157	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090672 vs DACT3 — OV

Explore this scatter interactively →