Telomerase RNA localization

Across TCGA cell cohorts, RNA activity of the Telomerase RNA localization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PEPD, GIGYF2, and ZNF233, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PEPD grouped by Telomerase RNA localization-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PEPD →	-1.344	-0.167	.003	.004	3	4
URINARY_TRACT	GIGYF2 →	-0.547	-0.115	.003	.004	3	4
STOMACH	ZNF233 →	+0.756	+0.121	.002	.004	3	4
LARGE_INTESTINE	RAPGEF2 →	+0.756	+0.071	.001	.006	3	4
PANCREAS	FNDC10 →	+0.989	+0.065	.009	.002	3	4
KIDNEY	ZNF583 →	+1.002	+0.167	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PEPD by Telomerase RNA localization activity — BLOOD_Myeloma

Explore this box plot interactively →