Telomerase RNA localization

Across TCGA cell cohorts, RNA activity of the Telomerase RNA localization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF3E, NKRF, and CHMP2A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomerase RNA localization activity versus EIF3E in LUNG_NSCLC_LUSC (Pearson r = 0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	EIF3E →	+1.017	+0.234	.005	.003	3	5
SKIN	NKRF →	+0.625	+0.151	<.001	<.001	3	4
LUNG_NSCLC_LUAD	CHMP2A →	-0.832	-0.185	.001	.002	3	4
LUNG_NSCLC_LUAD	CALM3 →	-0.802	-0.126	<.001	.009	3	4
PANCREAS	NAGK →	-0.907	-0.150	.004	.003	3	4
LARGE_INTESTINE	RAB1A →	-0.470	-0.116	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090672 vs EIF3E — LUNG_NSCLC_LUSC

Explore this scatter interactively →