scaRNA localization to Cajal body

Across TCGA cell cohorts, RNA activity of the scaRNA localization to Cajal body pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C17orf78, LIN7B, and DCAF4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, scaRNA localization to Cajal body activity versus C17orf78 in KIDNEY (Pearson r = -0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	C17orf78 →	-0.080	-0.133	<.001	.001	3	6
LUNG_SCLC	LIN7B →	-1.215	-0.095	.001	.006	3	4
BLOOD_Myeloma	DCAF4 →	+0.806	+0.124	.008	.005	3	4
LARGE_INTESTINE	MTA2 →	+0.737	+0.141	.001	<.001	2	5
LIVER	NTMT1 →	+0.870	+0.148	.006	.009	3	3
LIVER	TYW5 →	+0.568	+0.133	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090666 vs C17orf78 — KIDNEY

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