Walking behavior

Across TCGA patient cohorts, RNA activity of the Walking behavior pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UCHL1, HIGD1A, and RNASEH2B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Walking behavior activity versus UCHL1 in LUAD (Pearson r = -0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	UCHL1 →	+0.891	+0.056	.001	<.001	3	5
GBM	HIGD1A →	+0.636	+0.050	<.001	.001	3	5
PDAC	RNASEH2B →	-0.273	-0.063	<.001	<.001	3	4
LUAD	SAFB →	-0.101	-0.048	.008	<.001	3	4
GBM	TCOF1 →	-0.382	-0.056	<.001	<.001	3	4
GBM	CXorf56 →	-0.250	-0.041	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090659 vs UCHL1 — LUAD

Explore this scatter interactively →