Walking behavior

pathway activity — cross-omics
GO:0090659Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Walking behavior pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL5P4, ERMN, and TTC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
PDACRPL5P4 →-0.304-0.714<.001.00834
GBMERMN →+1.602+0.823<.001<.00134
OVTTC1 →-0.344-0.192.005.00933
GBMHFE →-0.432-0.551.002.00833
UCECSEC24A →-0.448-0.755.001<.00133
PDACTMEM87B →-0.310-0.625<.001.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration