Telomeric loop disassembly

Across TCGA patient cohorts, RNA activity of the Telomeric loop disassembly pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOXM1, DKC1, and GRP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomeric loop disassembly activity versus FOXM1 in BRCA (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FOXM1 →	+0.754	+0.192	<.001	<.001	3	4
BRCA	DKC1 →	+0.437	+0.227	.001	.002	3	4
BRCA	GRP →	-0.876	-0.211	.006	<.001	3	4
LSCC	KIF11 →	+0.702	+0.275	.001	<.001	3	4
BRCA	CTSK →	-1.010	-0.244	<.001	.003	3	4
LSCC	KIF15 →	+0.583	+0.250	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090657 vs FOXM1 — BRCA

Explore this scatter interactively →