Telomeric loop disassembly

Across TCGA cell cohorts, RNA activity of the Telomeric loop disassembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RUNX2, GPLD1, and WDR41, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RUNX2 grouped by Telomeric loop disassembly-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	RUNX2 →	+3.277	+1.918	.003	.001	3	4
BONE	GPLD1 →	-1.045	-1.775	.008	<.001	3	4
BONE	WDR41 →	+1.317	+1.243	.006	.002	3	4
BONE	SPATS2L →	+2.333	+1.302	.004	<.001	3	4
LARGE_INTESTINE	RGCC →	-1.533	-0.468	.003	.009	3	4
STOMACH	ANKRA2 →	+0.689	+0.855	.005	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RUNX2 by Telomeric loop disassembly activity — BLOOD_Myeloma

Explore this box plot interactively →