Telomeric loop disassembly

Across TCGA cell cohorts, RNA activity of the Telomeric loop disassembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDX5, TMEM131L, and SLC16A3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomeric loop disassembly activity versus DDX5 in BLOOD_Leukemia (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DDX5 →	+1.029	+1.428	.001	.001	3	3
BLOOD_Leukemia	TMEM131L →	+1.796	+1.689	<.001	<.001	3	3
BLOOD_Leukemia	SLC16A3 →	-2.018	-1.341	.003	<.001	3	3
BLOOD_Leukemia	NEK10 →	+0.458	+1.573	.004	<.001	3	3
BLOOD_Leukemia	GALNT10 →	-0.965	-1.316	<.001	<.001	3	3
BLOOD_Leukemia	BRD7 →	+0.576	+1.110	.005	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090657 vs DDX5 — BLOOD_Leukemia

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