Response to oxygen-glucose deprivation

Across TCGA patient cohorts, RNA activity of the Response to oxygen-glucose deprivation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LRRFIP1, RPS6, and SLC4A2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to oxygen-glucose deprivation activity versus LRRFIP1 in GBM (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LRRFIP1 →	-0.327	-0.080	<.001	<.001	3	5
GBM	RPS6 →	-0.384	-0.065	.005	.004	2	5
UCEC	SLC4A2 →	-0.518	-0.075	.003	.005	3	4
GBM	SQOR →	-0.543	-0.056	.001	.002	3	4
GBM	BCHE →	+0.587	+0.071	.001	.001	3	4
COAD	TTC7B →	+0.437	+0.036	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090649 vs LRRFIP1 — GBM

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