Response to oxygen-glucose deprivation

Across TCGA patient cohorts, RNA activity of the Response to oxygen-glucose deprivation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TP53INP1, AIFM2, and CHCHD7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to oxygen-glucose deprivation activity versus TP53INP1 in LUAD (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TP53INP1 →	+0.348	+0.242	.006	.004	3	4
HNSC	AIFM2 →	-0.491	-0.286	.005	.004	3	3
CCRCC	CHCHD7 →	-0.209	-0.144	.004	.006	3	3
GBM	IFNLR1 →	-0.402	-0.461	.002	.001	3	3
CCRCC	THAP12P5 →	+0.086	+0.114	<.001	.009	3	3
BRCA	RPAP1 →	-0.392	-0.228	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090649 vs TP53INP1 — LUAD

Explore this scatter interactively →