Response to oxygen-glucose deprivation

Across TCGA patient cohorts, RNA activity of the Response to oxygen-glucose deprivation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNS3_Y780, RPS2_T292, and SGTB, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to oxygen-glucose deprivation activity versus TNS3_Y780 in OV (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TNS3_Y780 →	+2.136	+1.616	<.001	<.001	3	3
LUAD	RPS2_T292 →	-0.495	-0.345	<.001	<.001	3	2
BRCA	SGTB →	+0.249	+0.290	<.001	<.001	3	2
UCEC	SPEG_T2844 →	-0.948	-0.864	<.001	<.001	3	2
GBM	CENPC_S333 →	-1.373	-1.292	<.001	.001	3	2
PDAC	CYLD_S409 →	+0.622	+1.603	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090649 vs TNS3_Y780 — OV

Explore this scatter interactively →