Response to oxygen-glucose deprivation

Across TCGA cell cohorts, RNA activity of the Response to oxygen-glucose deprivation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APOL3, NUDT7, and MKNK2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, APOL3 grouped by Response to oxygen-glucose deprivation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	APOL3 →	-1.415	-1.148	.006	<.001	3	4
OVARY	NUDT7 →	+1.269	+1.276	.007	.001	3	4
SOFT_TISSUE	MKNK2 →	-1.262	-1.440	<.001	<.001	3	4
BLOOD_Myeloma	MSMO1 →	-1.291	-1.222	.008	.007	3	4
BREAST	CHP1 →	-0.604	-0.735	<.001	.001	3	4
BLOOD_Leukemia	TBC1D7 →	-1.034	-1.716	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

APOL3 by Response to oxygen-glucose deprivation activity — OVARY

Explore this box plot interactively →