Response to oxygen-glucose deprivation

Across TCGA cell cohorts, RNA activity of the Response to oxygen-glucose deprivation pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DPM1, EZH1, and ATP6AP1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DPM1 grouped by Response to oxygen-glucose deprivation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DPM1 →	-0.224	-0.451	.007	<.001	3	2
BLOOD_Leukemia	EZH1 →	-0.339	-0.393	<.001	<.001	3	2
BLOOD_Leukemia	ATP6AP1 →	-0.426	-0.484	.007	.004	3	2
BLOOD_Leukemia	P2RX5 →	-0.166	-0.501	.002	<.001	3	1
BLOOD_Leukemia	SUCO →	+0.380	+0.560	.001	<.001	3	1
SKIN	SLC5A1 →	+0.159	+0.242	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DPM1 by Response to oxygen-glucose deprivation activity — SKIN

Explore this box plot interactively →