Mitochondrial tRNA processing

Across TCGA patient cohorts, RNA activity of the Mitochondrial tRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL6ST, CIT, and GASK1B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial tRNA processing activity versus IL6ST in BRCA (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IL6ST →	-1.341	-0.248	.001	.001	2	5
PDAC	CIT →	+0.285	+0.084	.003	.008	3	4
PDAC	GASK1B →	-0.439	-0.107	<.001	.006	3	4
OV	TIMP3 →	-1.000	-0.115	.005	.003	3	4
OV	C1orf162 →	-0.628	-0.134	.005	.005	3	4
OV	IGKV1-9 →	-2.350	-0.181	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090646 vs IL6ST — BRCA

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