Mitochondrial tRNA processing

Across TCGA cell cohorts, RNA activity of the Mitochondrial tRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC35A2, SMOX, and FUNDC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial tRNA processing activity versus SLC35A2 in OESOPHAGUS (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SLC35A2 →	+0.732	+0.725	.001	.007	1	6
LUNG_NSCLC_LUSC	SMOX →	-2.487	-1.386	.001	<.001	3	4
SOFT_TISSUE	FUNDC1 →	+0.746	+1.142	<.001	<.001	3	4
LIVER	XPNPEP3 →	-0.971	-1.217	.004	.002	3	3
OESOPHAGUS	CEP128 →	-0.847	-1.050	.009	.001	3	3
OESOPHAGUS	SMURF2 →	-0.866	-1.123	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090646 vs SLC35A2 — OESOPHAGUS

Explore this scatter interactively →