Activation of GTPase activity

Across TCGA patient cohorts, RNA activity of the Activation of GTPase activity pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NFATC2, PPP1R12B, and LCP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Activation of GTPase activity activity versus NFATC2 in UCEC (Pearson r = 0.05).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NFATC2 →	+0.395	+0.049	<.001	<.001	3	8
COAD	PPP1R12B →	+0.703	+0.016	.001	.008	3	8
UCEC	LCP1 →	+0.598	+0.044	.001	<.001	3	7
OV	RPL5 →	-0.248	-0.042	<.001	<.001	3	7
COAD	RPS2 →	-0.263	-0.019	<.001	.001	3	7
COAD	RPS7 →	-0.472	-0.021	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090630 vs NFATC2 — UCEC

Explore this scatter interactively →