Activation of GTPase activity

Across TCGA patient cohorts, RNA activity of the Activation of GTPase activity pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRPF4B_S277, ACIN1_S698, and SCML2_S511, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Activation of GTPase activity activity versus PRPF4B_S277 in OV (Pearson r = -0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PRPF4B_S277 →	-1.017	-0.549	<.001	<.001	3	2
OV	ACIN1_S698 →	-1.874	-0.666	<.001	<.001	3	1
OV	SCML2_S511 →	+0.968	+0.540	<.001	.001	3	1
OV	SIK3 →	-0.475	-0.557	.002	<.001	3	1
OV	SSBP2_T333 →	-0.546	-0.491	<.001	.001	3	1
OV	SSRP1_S672 →	-0.754	-0.585	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090630 vs PRPF4B_S277 — OV

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