Activation of GTPase activity

Across TCGA cell cohorts, RNA activity of the Activation of GTPase activity pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMARCD2, CORO1C, and MBNL3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Activation of GTPase activity activity versus SMARCD2 in BREAST (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SMARCD2 →	-0.946	-0.230	.005	<.001	3	6
LUNG_NSCLC_LUAD	CORO1C →	+0.879	+0.263	<.001	<.001	3	6
BLOOD_Lymphoma	MBNL3 →	-1.325	-0.254	.007	.002	3	6
BLOOD_Leukemia	RNH1 →	+0.907	+0.201	.001	.001	3	6
KIDNEY	DZIP1 →	+2.540	+0.246	.002	.009	3	5
OVARY	ABL2 →	+1.648	+0.476	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090630 vs SMARCD2 — BREAST

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