Sensory organ morphogenesis

Across TCGA patient cohorts, RNA activity of the Sensory organ morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BBS7, SMOC2, and CNPY4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sensory organ morphogenesis activity versus BBS7 in UCEC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BBS7 →	+0.431	+0.057	<.001	<.001	3	7
UCEC	SMOC2 →	+0.749	+0.042	.001	.003	3	7
OV	CNPY4 →	+0.451	+0.035	<.001	<.001	3	7
BRCA	FKBP7 →	+0.445	+0.015	<.001	<.001	3	7
PDAC	ISLR →	+0.705	+0.019	<.001	<.001	3	7
BRCA	DDX21_S89 →	-0.863	-0.016	<.001	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090596 vs BBS7 — UCEC

Explore this scatter interactively →