Sensory organ morphogenesis

Across TCGA patient cohorts, RNA activity of the Sensory organ morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NKG7, CTSC, and IL21, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sensory organ morphogenesis activity versus NKG7 in COAD (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	NKG7 →	-1.058	-1.022	<.001	<.001	3	3
COAD	CTSC →	-0.450	-0.554	<.001	.002	3	3
COAD	IL21 →	-0.308	-0.913	<.001	<.001	3	3
BRCA	ICOS →	-1.248	-1.175	.007	.006	3	3
COAD	PRF1 →	-0.689	-0.714	.004	.001	3	3
COAD	TIGIT →	-0.561	-0.690	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090596 vs NKG7 — COAD

Explore this scatter interactively →