Sensory organ morphogenesis

Across TCGA cell cohorts, RNA activity of the Sensory organ morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SFXN5, KIF1A, and MYB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SFXN5 grouped by Sensory organ morphogenesis-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SFXN5 →	-0.921	-1.173	.009	<.001	3	3
LARGE_INTESTINE	KIF1A →	+0.488	+0.629	.005	.001	3	3
BONE	MYB →	+2.310	+1.645	.001	<.001	3	3
CNS	EIF2S3 →	+0.613	+0.921	<.001	<.001	3	3
CNS	CAMK2N1 →	-1.444	-0.543	.001	.007	3	3
BONE	HOXD4 →	+1.938	+1.242	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SFXN5 by Sensory organ morphogenesis activity — STOMACH

Explore this box plot interactively →