Sensory organ morphogenesis

Across TCGA cell cohorts, RNA activity of the Sensory organ morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C4BPA, DPF3, and CDKN2C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C4BPA grouped by Sensory organ morphogenesis-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	C4BPA →	+0.148	+0.048	<.001	.004	3	5
URINARY_TRACT	DPF3 →	+0.305	+0.060	.001	.001	3	4
BONE	CDKN2C →	+0.278	+0.036	.001	.006	3	4
BLOOD_Leukemia	WDFY4 →	+0.321	+0.055	.002	.001	3	4
BLOOD_Leukemia	PPIE →	+0.278	+0.030	.007	.002	3	4
SKIN	AGO2 →	+0.226	+0.042	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C4BPA by Sensory organ morphogenesis activity — STOMACH

Explore this box plot interactively →