Sensory organ morphogenesis

Across TCGA cell cohorts, RNA activity of the Sensory organ morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POPDC2, BCL2A1, and SERPINB12, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POPDC2 grouped by Sensory organ morphogenesis-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	POPDC2 →	-0.140	-0.175	.002	.003	3	4
SOFT_TISSUE	BCL2A1 →	+0.465	+0.273	<.001	.001	3	3
BLOOD_Lymphoma	SERPINB12 →	+0.231	+0.238	<.001	.002	3	3
OESOPHAGUS	TUBG1 →	+0.353	+0.242	<.001	.002	3	3
SOFT_TISSUE	RALA →	+0.356	+0.404	.001	.006	3	3
LARGE_INTESTINE	TBL3 →	-0.373	-0.236	.008	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POPDC2 by Sensory organ morphogenesis activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →