Sensory organ morphogenesis

Across TCGA cell cohorts, RNA activity of the Sensory organ morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FLOT1, METTL15, and ADAM19, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sensory organ morphogenesis activity versus FLOT1 in CNS (Pearson r = -0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FLOT1 →	-0.890	-0.179	.006	.001	3	4
SOFT_TISSUE	METTL15 →	-0.557	-0.277	.007	.002	3	4
KIDNEY	ADAM19 →	+2.071	+0.154	.005	.004	3	3
SKIN	EID2 →	-0.595	-0.269	<.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	ATP6V0D1 →	-1.072	-0.262	.006	.006	3	3
LUNG_NSCLC_LUAD	SLC35E4 →	-0.783	-0.157	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090596 vs FLOT1 — CNS

Explore this scatter interactively →