Inflammatory response to wounding

Across TCGA patient cohorts, RNA activity of the Inflammatory response to wounding pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CASP4LP, SPARCL1, and GNG2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inflammatory response to wounding activity versus CASP4LP in HNSC (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CASP4LP →	+0.576	+0.268	.001	<.001	3	5
BRCA	SPARCL1 →	+0.881	+0.157	.001	.001	3	5
OV	GNG2 →	+0.663	+0.198	.007	.001	3	5
HNSC	MGP →	+1.558	+0.229	<.001	<.001	3	4
HNSC	HNMT →	+0.608	+0.157	.003	.005	3	4
BRCA	FLI1 →	+0.538	+0.241	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090594 vs CASP4LP — HNSC

Explore this scatter interactively →