Inflammatory response to wounding

Across TCGA cell cohorts, RNA activity of the Inflammatory response to wounding pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BBOF1, SPDYE6, and THADA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BBOF1 grouped by Inflammatory response to wounding-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	BBOF1 →	+0.820	+1.050	<.001	.004	3	5
LUNG_NSCLC_LUSC	SPDYE6 →	+0.853	+1.495	.007	<.001	3	4
KIDNEY	THADA →	+0.437	+0.971	.001	.003	3	4
OESOPHAGUS	MYH3 →	+1.655	+1.536	<.001	.008	3	4
OESOPHAGUS	MED14 →	+0.753	+1.542	.008	.001	2	5
CNS	NACC2 →	+1.195	+1.127	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BBOF1 by Inflammatory response to wounding activity — SKIN

Explore this box plot interactively →