Inflammatory response to wounding

Across TCGA cell cohorts, RNA activity of the Inflammatory response to wounding pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAE1, KIR2DS4, and FAT1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAE1 grouped by Inflammatory response to wounding-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	RAE1 →	+0.148	+2.044	.008	.004	2	2
KIDNEY	KIR2DS4 →	+0.290	+2.044	.006	.004	2	2
CNS	FAT1 →	+0.313	+1.660	.005	.001	2	1
CNS	MYNN →	-0.280	-1.764	.003	.005	2	1
CNS	PREP →	+0.194	+1.660	.007	.001	2	1
CNS	MAST2 →	+0.335	+1.764	<.001	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAE1 by Inflammatory response to wounding activity — KIDNEY

Explore this box plot interactively →