Inflammatory response to wounding

Across TCGA cell cohorts, RNA activity of the Inflammatory response to wounding pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLA1, SLC4A3, and AMPD1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inflammatory response to wounding activity versus POLA1 in CNS (Pearson r = 0.93).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	POLA1 →	+0.633	+1.848	<.001	<.001	3	1
CNS	SLC4A3 →	-1.146	-1.870	.006	<.001	3	1
CNS	AMPD1 →	+0.066	+1.794	<.001	<.001	3	1
CNS	KLRC1 →	+0.060	+1.812	.006	<.001	3	1
CNS	PRSS53 →	-0.776	-1.900	.008	<.001	3	1
CNS	EXOC3 →	-1.200	-1.900	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090594 vs POLA1 — CNS

Explore this scatter interactively →