Regulation of membrane permeability

Across TCGA patient cohorts, RNA activity of the Regulation of membrane permeability pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, SEPTIN4_S432, and FAM83H, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of membrane permeability activity versus RPL5 in GBM (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPL5 →	-0.194	-0.032	<.001	<.001	3	7
PDAC	SEPTIN4_S432 →	+0.503	+0.024	.001	<.001	3	6
HNSC	FAM83H →	-0.644	-0.055	<.001	.005	3	5
PDAC	JPT1_S131 →	-0.679	-0.030	<.001	<.001	3	5
CCRCC	SEPTIN4 →	+0.390	+0.037	.001	<.001	3	5
CCRCC	SPAG9 →	-0.269	-0.031	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090559 vs RPL5 — GBM

Explore this scatter interactively →