Regulation of membrane permeability

Across TCGA patient cohorts, RNA activity of the Regulation of membrane permeability pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM83D, KIF23, and CENPE, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of membrane permeability activity versus FAM83D in BRCA (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FAM83D →	-1.010	-0.212	.004	.003	3	5
GBM	KIF23 →	-0.600	-0.177	.006	.003	3	5
OV	CENPE →	-1.072	-0.252	<.001	.003	2	6
GBM	FAXDC2 →	+0.502	+0.147	.002	.008	3	5
BRCA	SKA1 →	-0.835	-0.237	.006	<.001	3	5
COAD	PGM5 →	+0.973	+0.253	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090559 vs FAM83D — BRCA

Explore this scatter interactively →