Regulation of membrane permeability

Across TCGA cell cohorts, RNA activity of the Regulation of membrane permeability pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are P3H3, NBPF9, and MED17, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, P3H3 grouped by Regulation of membrane permeability-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	P3H3 →	-2.060	-0.983	<.001	<.001	3	6
CNS	NBPF9 →	-0.571	-0.931	.003	.002	3	5
LUNG_NSCLC_LUAD	MED17 →	-0.587	-0.833	.002	.004	3	5
URINARY_TRACT	ARHGDIA →	-1.259	-1.902	.002	<.001	3	5
LUNG_NSCLC_LUSC	DYRK3 →	-2.043	-1.658	<.001	<.001	3	5
CNS	RAB40AL →	-0.205	-1.108	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

P3H3 by Regulation of membrane permeability activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →