Sphingolipid mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Sphingolipid mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBL, SAC3D1, and PYCR3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sphingolipid mediated signaling pathway activity versus FBL in LSCC (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FBL →	-0.734	-0.596	<.001	<.001	3	4
COAD	SAC3D1 →	-0.549	-0.598	.004	.001	3	4
COAD	PYCR3 →	-0.600	-0.512	<.001	.004	3	4
COAD	ALYREF →	-0.455	-0.473	.001	.005	3	4
LSCC	TMC5 →	+1.101	+0.657	<.001	<.001	3	4
LSCC	NBEAL1 →	+0.324	+0.601	.008	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090520 vs FBL — LSCC

Explore this scatter interactively →