Sphingolipid mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Sphingolipid mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMPD3_S209, ZZEF1_S2049, and EZR_S536, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sphingolipid mediated signaling pathway activity versus SMPD3_S209 in OV (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SMPD3_S209 →	+1.740	+0.902	<.001	<.001	3	3
LUAD	ZZEF1_S2049 →	+0.815	+1.343	<.001	<.001	3	3
CCRCC	EZR_S536 →	+0.894	+0.220	<.001	<.001	3	3
BRCA	PKN2_T628 →	+1.158	+1.846	<.001	<.001	3	3
LSCC	TRIP12_S1322 →	-0.689	-0.778	<.001	<.001	3	3
LSCC	SUZ12_S541 →	-0.641	-1.015	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090520 vs SMPD3_S209 — OV

Explore this scatter interactively →