Sphingolipid mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Sphingolipid mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MACROD1, IFT46, and PRAG1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MACROD1 grouped by Sphingolipid mediated signaling pathway-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MACROD1 →	-1.451	-1.248	.008	.005	3	4
LUNG_NSCLC_LUSC	IFT46 →	+1.529	+1.321	.005	.005	3	4
SOFT_TISSUE	PRAG1 →	+2.571	+1.805	<.001	<.001	3	4
STOMACH	TXNDC15 →	+1.082	+1.362	.001	<.001	3	3
STOMACH	PLK4 →	+0.723	+1.106	.003	.004	2	4
STOMACH	CADM1 →	+2.773	+1.120	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MACROD1 by Sphingolipid mediated signaling pathway activity — STOMACH

Explore this box plot interactively →