Epiboly

Across TCGA patient cohorts, RNA activity of the Epiboly pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MSRB3, MYL9, and TPM2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epiboly activity versus MSRB3 in BRCA (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MSRB3 →	+0.884	+0.575	<.001	.002	3	8
LSCC	MYL9 →	+1.126	+0.428	<.001	<.001	3	8
OV	TPM2 →	+1.445	+0.721	<.001	.002	3	8
OV	MEIS3 →	+0.636	+0.455	.002	.003	3	8
OV	ACTA2 →	+2.341	+0.696	<.001	<.001	3	7
OV	PMP22 →	+0.728	+0.561	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090504 vs MSRB3 — BRCA

Explore this scatter interactively →