Epiboly

Across TCGA cell cohorts, RNA activity of the Epiboly pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COQ8A, UBTD1, and EHHADH, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COQ8A grouped by Epiboly-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	COQ8A →	-0.835	-0.821	.004	.008	3	4
LARGE_INTESTINE	UBTD1 →	+0.964	+0.744	.001	.002	3	4
LIVER	EHHADH →	-1.418	-1.043	.001	.009	3	4
LUNG_NSCLC_LUAD	PAQR7 →	+0.833	+0.435	.003	.002	3	4
LUNG_NSCLC_LUAD	C1orf210 →	-1.867	-0.494	.003	.005	3	4
BONE	AFF4 →	+1.073	+0.536	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COQ8A by Epiboly activity — LARGE_INTESTINE

Explore this box plot interactively →