Mesenchymal cell migration

Across TCGA patient cohorts, RNA activity of the Mesenchymal cell migration pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SERPING1, COL1A2, and PCOLCE, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesenchymal cell migration activity versus SERPING1 in OV (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SERPING1 →	+0.667	+0.057	.001	<.001	3	8
GBM	COL1A2 →	+0.691	+0.030	.001	.002	3	8
OV	PCOLCE →	+1.078	+0.054	<.001	<.001	3	8
OV	LAMB1 →	+0.467	+0.046	.001	<.001	3	7
OV	ITIH1 →	+1.045	+0.060	<.001	<.001	3	7
CCRCC	PPM1F →	+0.322	+0.048	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090497 vs SERPING1 — OV

Explore this scatter interactively →