Mesenchymal cell migration

Across TCGA cell cohorts, RNA activity of the Mesenchymal cell migration pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NNMT, TMSB10, and EDC3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NNMT grouped by Mesenchymal cell migration-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	NNMT →	-6.478	-1.227	<.001	.004	3	4
KIDNEY	TMSB10 →	-0.794	-1.191	.001	.001	3	4
LUNG_SCLC	EDC3 →	+0.563	+0.721	.001	.004	3	4
BONE	TTLL12 →	+1.073	+1.224	.001	.004	3	4
BONE	COL8A1 →	-4.640	-1.244	<.001	.004	3	4
BONE	PTPN13 →	+2.457	+1.306	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NNMT by Mesenchymal cell migration activity — BONE

Explore this box plot interactively →