Mesenchymal cell migration

Across TCGA cell cohorts, RNA activity of the Mesenchymal cell migration pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WNT1, DNAJB6, and PSG8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WNT1 grouped by Mesenchymal cell migration-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	WNT1 →	-0.175	-0.068	.004	.006	3	5
OVARY	DNAJB6 →	+0.160	+0.103	.006	.004	3	4
LUNG_NSCLC_LUSC	PSG8 →	-0.376	-0.130	<.001	<.001	3	4
STOMACH	ARHGEF11 →	+0.119	+0.104	.003	<.001	3	4
STOMACH	DEPDC1 →	+0.210	+0.112	.005	.002	3	4
KIDNEY	S100A8 →	+0.353	+0.128	.004	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WNT1 by Mesenchymal cell migration activity — LARGE_INTESTINE

Explore this box plot interactively →