Mesenchymal cell migration

Across TCGA cell cohorts, RNA activity of the Mesenchymal cell migration pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FN1, COX15, and ATP10D, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesenchymal cell migration activity versus FN1 in SOFT_TISSUE (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	FN1 →	+6.440	+0.348	.001	.007	2	6
LIVER	COX15 →	-0.812	-0.375	.001	<.001	3	4
LUNG_NSCLC_LUAD	ATP10D →	+0.707	+0.176	.003	.007	3	4
KIDNEY	MROH6 →	-1.205	-0.294	.001	.004	3	4
LIVER	PRKAB1 →	-0.688	-0.311	.003	<.001	3	3
LIVER	DENND4C →	-0.638	-0.282	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090497 vs FN1 — SOFT_TISSUE

Explore this scatter interactively →