Catecholamine uptake

Across TCGA patient cohorts, RNA activity of the Catecholamine uptake pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DPYSL3, MAP1B_S614, and TBC1D22B_S141, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Catecholamine uptake activity versus DPYSL3 in OV (Pearson r = 0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DPYSL3 →	-0.484	-0.091	.001	<.001	3	6
CCRCC	MAP1B_S614 →	-0.797	-0.057	.004	.009	3	5
COAD	TBC1D22B_S141 →	+0.209	+0.045	.009	.008	3	5
COAD	COL5A2 →	-0.520	-0.059	<.001	.003	3	5
HNSC	CDH11 →	-0.616	-0.114	<.001	<.001	3	5
UCEC	LAMC1 →	-0.542	-0.082	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090493 vs DPYSL3 — OV

Explore this scatter interactively →