Catecholamine uptake

pathway activity — cross-omics
GO:0090493Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Catecholamine uptake pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HBA1, HBB, and TIMM10B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCAHBA1 →+1.022+0.104.004.00835
LSCCHBB →+1.312+0.091.001.00235
BRCATIMM10B →-0.341-0.131.005.00333
BRCATAF7 →-0.497-0.142<.001.00233
BRCAMIR587 →+0.151+0.200.006.00433
BRCAITPKB-IT1 →+0.200+0.134.005<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration