Intracellular glutamate homeostasis

Across TCGA patient cohorts, RNA activity of the Intracellular glutamate homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DSCC1, SLC1A1, and TTC9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular glutamate homeostasis activity versus DSCC1 in BRCA (Pearson r = 0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DSCC1 →	-0.412	-0.048	<.001	.001	3	5
BRCA	SLC1A1 →	+0.860	+0.079	<.001	<.001	3	4
UCEC	TTC9 →	+0.585	+0.087	<.001	<.001	3	4
LSCC	TNIK →	+0.279	+0.053	.007	.009	3	4
UCEC	DHRS7 →	+0.477	+0.084	.001	.005	3	4
LSCC	G6PD →	+0.648	+0.073	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090461 vs DSCC1 — BRCA

Explore this scatter interactively →