Intracellular glutamate homeostasis

Across TCGA cell cohorts, RNA activity of the Intracellular glutamate homeostasis pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEZ6, PSMA5, and TSPAN7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SEZ6 grouped by Intracellular glutamate homeostasis-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SEZ6 →	+0.272	+0.197	.004	.007	2	5
SKIN	PSMA5 →	-0.231	-0.180	.003	.008	3	3
BREAST	TSPAN7 →	+0.198	+0.327	.002	.001	3	3
BREAST	IKZF2 →	+0.232	+0.358	<.001	.001	3	3
BREAST	PHLPP2 →	+0.224	+0.356	<.001	<.001	3	3
LUNG_NSCLC_LUSC	RASAL3 →	-0.274	-0.233	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SEZ6 by Intracellular glutamate homeostasis activity — OVARY

Explore this box plot interactively →