Intracellular glutamate homeostasis

Across TCGA cell cohorts, RNA activity of the Intracellular glutamate homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLS, CPEB2, and SESN1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular glutamate homeostasis activity versus GLS in BREAST (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GLS →	+1.772	+0.370	.002	.001	3	8
BLOOD_Lymphoma	CPEB2 →	+1.051	+0.191	<.001	.004	3	5
KIDNEY	SESN1 →	-2.186	-0.101	<.001	.001	3	5
BLOOD_Lymphoma	PIGK →	+1.390	+0.174	<.001	<.001	3	4
CNS	PEAK1 →	+1.157	+0.173	<.001	<.001	3	4
BREAST	CAV2 →	+3.983	+0.373	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090461 vs GLS — BREAST

Explore this scatter interactively →